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Carbonic acid bis(2-methoxyphenyl) ester. Guaiacol carbonic acid neutral ester. UNII-Q71XPQ6R29. NSC 37138. MLS002637719.
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[Article in Russian] OSTROVSKII MM. PMID: 13731536 [PubMed - indexed for MEDLINE] MeSH Terms. Benzaldehydes/toxicity* Drug Industry* Guaiacol/toxicity* Industry* Substances. Benzaldehydes; Guaiacol; vanillin Guaiacol is a precursor to various flavorants such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as a dye in chemical reactions as oxygen will turn guaiacol from colorless to brown. Acute toxicity of thioguaiacol and of versalide in rodents. Butterworth KR, Mason PL. PMID: 7327477 [PubMed - indexed for MEDLINE] MeSH Terms.
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Definition from advance sheets of Gould's "New Medical Dictionary." 2. Nagelvoort on "Poisonous Creasote," Bulletin of Pharmacy , Vol. vi, p. 557.
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Causes skin and eye irritation. Causes serious eye irritation. Harmful to aquatic life Oxidation of guaiacol is the rate-determining step for peroxidase activity. The specific activity of the control HRP enzyme was compared with the bioCNT-HRP complex, showing that the calculated specific activity of free HRP was ~ 1.46 μM/s (100%) and that of bioCNT-HRP was ~ 1.25 μM/s, which is approximately equal to 85% relative activity of the free enzyme concentration (Fig. 7A). An agent thought to have disinfectant properties and used as an expectorant.
H302 (99.94%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (97.42%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (99.88%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Precautionary Statement Codes
Human systemic effects by ingestion: tremors and gastrointestinal changes. Human mutation data reported. An eye and severe skin irritant.
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EINECS 202-252-9. BRN 1862340. P-Methylguaicol.
It also can be used as a dye in chemical reactions as oxygen will turn guaiacol from colorless to brown. Acute toxicity of thioguaiacol and of versalide in rodents. Butterworth KR, Mason PL. PMID: 7327477 [PubMed - indexed for MEDLINE] MeSH Terms. Animals; Female; Flavoring Agents/toxicity* Guaiacol/analogs & derivatives* Guaiacol/toxicity; Male; Naphthalenes/toxicity* Perfume/toxicity* Rats; Rats, Inbred Strains; Sex Factors; Tetrahydronaphthalenes/toxicity* Substances
Guaiacol carbonate | C15H14O5 | CID 11104 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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Guaiacol is a precursor to various flavorants, such as eugenol. An estimated 85% of the world's supply of vanillin comes from guaiacol. The route entails condensation of glyoxylic acid with guaiacol to give mandelic acid, which is oxidized to produce a phenylglyoxylic acid. This acid undergoes a decarboxylation to afford vanillin.
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Guaiacol is a precursor to various flavorants, such as eugenol. An estimated 85% of the world's supply of vanillin comes from guaiacol. The route entails condensation of glyoxylic acid with guaiacol to give mandelic acid, which is oxidized to produce a phenylglyoxylic acid. This acid undergoes a decarboxylation to afford vanillin. Guaiacol - Toxicity Data: Oral LDLO (human): 43 mg/kg; Oral LD50 (rat): 520 mg/kg; Subcutaneous LDLO (rat): 900 mg/kg; Oral LD50 (mouse): 621 mg/kg; Information on Toxicological Effects: Guaiacol - Investigated as a mutagen and primary irritant. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.